Uncontrolled and Resistant Hypertension Increases with Advanced Diabetic Nephropathy

The prevalence of uncontrolled and resistant hypertension increased with advanced diabetic nephropathy in aDiabetes Care study of 3678 patients with type 1 diabetes. In patients with normal urinary albumin excretion, 14.1% were on antihypertensive treatment and 74.6% had uncontrolled blood pressure despite treatment. The corresponding figures were 60.5 and 71.2% for microalbuminuric, 90.3% and 80.0% for macroalbuminuric, 88.6% and 88.1% for dialysis, and 91.2% and 90.4% for kidney transplanted patients. The prevalence of resistant hypertension was 1.2% in the normoalbuminuric, 4.7% in the microalbuminuric, 28.1% in the macroalbuminuric, 36.6% in the dialysis, and 26.3% in the kidney transplant groups.