Low Testosterone May be Associated with Increased Risk of Premature Death in Men with CKD Stages 3–4

A recent study of 2419 men with CKD stages 3–4 found that patients within the second lowest quintile of testosterone level had a 53% increased risk of dying over a median follow-up of 2.3 years compared with men in the highest quintile. Each 1 log unit increment in serum testosterone level was associated with a 30% decreased risk of death. Higher eGFR levels and being of African American descent were linked with decreased risks of hypogonadism (total testosterone <350ng/dL). Diabetes and increasing BMI were associated with increased risks, according to the American Journal of Kidney Diseases study.