Researchers have uncovered a link between an increased dosage of insulin and a heightened risk of premature death and other events in patients with type 2 diabetes. The observational study included 6484 patients with type 2 diabetes who progressed to treatment with insulin monotherapy and were followed for an average of 3.3 years. Increased risks in relation to 1-unit increases in insulin dose were 54% for all-cause mortality, 37% for major adverse cardiovascular events, and 35% for cancer during follow-up. The results are published in Diabetes, Obesity, and Metabolism.
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