In a study of 9724 adults who participated in NHANES 1999–2004, each 2.2 mEq/L increment in serum bicarbonate level among women was associated with a 0.007 g/cm² greater lumbar bone mineral density (BMD) and 0.005 g/cm² greater total BMD. Among men, it was associated with a 0.008 g/cm² increase in lumbar BMD and a non-significant increase in total BMD. In a subgroup analysis of 2805 pre- and post-menopausal women, there was a significant association between serum bicarbonate levels and total BMD only in postmenopausal women. Thefindings are published in the American Journal of Kidney Diseases.
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