Drug-induced acute interstitial nephritis (AIN), a common cause of acute kidney injury, occurred in 87% of elderly individuals in a recent study, compared to 64% of younger participants. AIN due to proton pump inhibitors was more common in elderly participants compared to younger ones (18% vs. 6%), while AIN due to autoimmune or systemic causes was more common among younger individuals (27% vs. 7%). The 2 most common culprit drugs in the elderly were penicillin and omeprazole. The Kidney International study investigated the causes and characteristics of AIN in 45 elderly (≥65 years) and 88 younger (18–64 years) adults.
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