Androgen Deprivation Therapy Linked to Acute Kidney Injury

In a study of more than 10,000 patients with newly diagnosed nonmetastatic prostate cancer, those who used androgen deprivation therapy had nearly 2.5 times the odds of developing acute kidney injury compared with those who never used the therapy, which corresponds to a rate difference of 4.43/1000 persons per year. This association was mainly driven by a combined treatment of gonadotropin-releasing hormone agonists with oral antiandrogens, estrogens, other combination therapies, and gonadotropin-releasing hormone agonists. Bilateral orchiectomy and monotherapy with an antiandrogen did not significantly affect the risk of acute kidney injury. The findings are published in JAMA.