Obesity Susceptibility Genes Associated With Insulin Sensitivity.

MedWire  (4/3, Robertson) reports, "The SH2B adaptor protein 1 gene (SH2B1) previously shown to be associated with body mass index (BMI) is also associated with insulin sensitivity," according to a study  published online in the journal Diabetic Medicine. "In addition, two other BMI-susceptibility loci (neuronal growth regulator 1 [NEGR1] and mitochondrial carrier 1 [MTCH1]) may also play a role in sensitivity to insulin," researchers reported after evaluating "926 men (aged 71 years) without diabetes, who underwent a euglycemic-hyperinsulinemic clamp and genotyping for 32 BMI-susceptibility loci."