MedPage Today
(4/5, Walsh) reports, "Patients with Clostridium difficile infection
and underlying impaired renal function who were treated with fidaxomicin
fared better than those given vancomycin," according to a study
presented at the annual meeting of the Society of Hospital Medicine.
"Patients with toxin-positive C. difficile infection and creatinine
clearance below normal (90 mL/min/1.73 m2) were half as likely to
experience a recurrence of diarrhea if treated with fidaxomicin (OR
0.46, 95% CI 0.32 to 0.66, P<0.001),"
researchers reported. What's more, "patients with moderate to severe
renal impairment who received fidaxomicin (Dificid) had almost twice the
likelihood of experiencing a four-week sustained response compared with
those given vancomycin (OR 1.89, 95% CI 1.41 to 2.53, P<0.001)," the
study found. 
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