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Saturday, September 7, 2013

New Therapeutic Approach for Polycystic Kidney Disease?

Research suggests a possible therapeutic approach for autosomal dominant polycystic kidney disease (ADPKD) by placing normal polycystin-1 protein back into patients’ cells to correct a defect. A new JASN studyfound polycystin-1 protein may help shepherd polycystin-2 to a cell’s antenna, or cilium, and this process is defective in induced pluripotent stem cells derived from patients with ADPKD. The accompanying editorialstates that the study lays the groundwork for using induced pluripotent stem cells in PKD research.

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