Researchers have uncovered a link between an increased dosage of insulin and a heightened risk of premature death and other events in patients with type 2 diabetes. The observational study included 6484 patients with type 2 diabetes who progressed to treatment with insulin monotherapy and were followed for an average of 3.3 years. Increased risks in relation to 1-unit increases in insulin dose were 54% for all-cause mortality, 37% for major adverse cardiovascular events, and 35% for cancer during follow-up. The results are published in Diabetes, Obesity, and Metabolism.
Thursday, December 11, 2014
Wednesday, December 10, 2014
In continuing coverage, ABC World News (12/9, story 7, 1:10, Muir) Chief Medical Editor Dr. Richard Besser reported on a study from Express Scripts that looked at 36 million prescriptions and found that “nearly half of those patients who are described a narcotic and took it for more than 30 days, they were still on it three years later.” Dr. Besser said these drugs “are meant for short-term use,” and according to the CDC “46 people die from narcotic overdose, when they are combined with anxiety medication or sleeping pills” every day.
TIME (12/10, Sifferlin) reports that although “the rate of Americans using pain medications like codeine, morphine, oxycodone and hydrocodone long term has remained stable in the last five years,” the amount “of medication they take has increased.” The report found that “use was most rampant in small Southeastern cities, and two-thirds of patients were prescribed the drugs by two or more physicians.” Nearly “40% filled their prescriptions at multiple pharmacies.”
CBS News (12/10) reports on its website that according to the National Institute on Drug Abuse, “the U.S. accounts for only 5 percent of the world’s population, yet as a country we consume at least 75 percent of all opioid prescription drugs.”
Tuesday, December 9, 2014
Saturday, December 6, 2014
Thursday, December 4, 2014
In a study of 235 incident dialysis patients, those who took iron supplements had a 78% decreased risk of death over a median follow-up of 34 months. They also had a 69% reduced risk of death due to cardiovascular and sepsis-related causes. Increasing ferritin concentrations in patients with normal C-reactive protein was associated with a decreased risk of death, whereas in patients with elevated C-reactive protein values, ferritin levels >800 ng/mL were linked with increased mortality. For the PLOS One study, 191 patients received intravenous iron, 13 patients received oral iron, and 31 patients never received iron supplements.