Wednesday, March 26, 2014
Current Use of Proton Pump Inhibitors Increases Risk of Developing Acute Interstitial Nephritis
Current use of a proton pump inhibitor (omeprazole, pantoprazole, or lansoprazole) was linked with a fivefold increased risk of acute interstitial nephritis, relative to past use, in a Kidney International study of 572,661 patients without a history of renal disease who started a new episode of proton pump inhibitor use between 2005 and 2009. The crude incidence rates of acute interstitial nephritis per 100,000 person-years were 11.98 for current proton pump inhibitor use and 1.68 for past use. Greater caution concerning the use of proton pump inhibitors is warranted considering the extremely large number of patients using the drugs.