Blood and Pulse Pressures Affect Kidney Outcomes in Patients with Type 2 Diabetes

Compared to type 2 diabetics with systolic blood pressure (SBP) of 105 to 129 mm Hg, those with SBP of 130 to 139 mm Hg were 88% more likely to have worsening albumin-to-creatinine ratio (ACR) and those with SBP ≥140 mm Hg were 2.5-fold more likely. Compared to a pulse pressure (PP) of 40 to 49 mm Hg, PP <40 was associated with a 64% lower risk of worsening ACR and PP ≥60 with a 2.4-fold increased risk. Patients with SBP ≥140 mm Hg were 15% more likely than those with SBP <140 mm Hg to experience eGFR worsening for each 1% A1C increase. The Diabetes Carestudy included 1791 diabetic veterans.