(1/19, Dallas) reports, "Researchers have identified a DNA sequence
that appears to speed up the progression of lupus." Specifically,
"researchers identified a particular DNA sequence, called HS1.2," which
"leads to increased activation of the 'transcription factor NF-KB'" and
"boosts the production of antibodies that attack the tissues, and
increases the aggressiveness of the disease." The study authors
concluded, "Our results suggest that new drugs that turn off the
enhancer HS1.2, or inhibit its effect on NF-KB, can
stop the disease without the need for immunosuppressive drugs or other
therapies with many side effects." The study was published in the Annals
of the Rheumatic Diseases.
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