Bloomberg News 
(8/9, Pettypiece) reports, "A tuberculosis vaccine in use for 90 years
may help reverse type 1 diabetes and eliminate the life-long need for
insulin injections, say Harvard University researchers raising money to
conduct large, human studies." This "vaccine, called bacillus
Calmette-Guérin, or BCG, stimulated production of a protein that killed
the insulin-attacking cells, according to" a study published online Aug. 8 in the journal PLoS One.
(8/9, Pettypiece) reports, "A tuberculosis vaccine in use for 90 years
may help reverse type 1 diabetes and eliminate the life-long need for
insulin injections, say Harvard University researchers raising money to
conduct large, human studies." This "vaccine, called bacillus
Calmette-Guérin, or BCG, stimulated production of a protein that killed
the insulin-attacking cells, according to" a study published online Aug. 8 in the journal PLoS One.
"There were no changes, however, in the need for insulin among those with longstanding diabetes who got the vaccine," HealthDay
(8/9, Gordon) reports. "The vaccine works by increasing levels of a
substance known as tumor necrosis factor (TNF). High doses of TNF can
be toxic, but the vaccine doesn't appear to raise levels of TNF too
high."
(8/9, Gordon) reports. "The vaccine works by increasing levels of a
substance known as tumor necrosis factor (TNF). High doses of TNF can
be toxic, but the vaccine doesn't appear to raise levels of TNF too
high."
WebMD
(8/9, DeNoon) explains, "In the study, six insulin-dependent adults
with type 1 diabetes received either two doses of BCG or two fake
vaccinations." Next, "the two groups were compared to one another, to
57 diabetes patients, and to 16 people without diabetes." In the three
individuals who got the vaccine, "'Bad' anti-insulin T cells began dying
off, new 'good' regulatory T cells increased, [and] there were signs of
new, albeit temporary, insulin production from pancreatic beta cells."
(8/9, DeNoon) explains, "In the study, six insulin-dependent adults
with type 1 diabetes received either two doses of BCG or two fake
vaccinations." Next, "the two groups were compared to one another, to
57 diabetes patients, and to 16 people without diabetes." In the three
individuals who got the vaccine, "'Bad' anti-insulin T cells began dying
off, new 'good' regulatory T cells increased, [and] there were signs of
new, albeit temporary, insulin production from pancreatic beta cells."
According to MedPage Today
(8/9, Fiore), "From their findings, the researchers concluded that the
vaccine, at low doses, appears safe and well tolerated, and that it
likely 'ameliorates the advanced autoimmune process underlying type 1
diabetes by stimulating TNF, which selectively kills only
disease-causing cells.'" Reuters (8/9, Begley) also covers the story.
(8/9, Fiore), "From their findings, the researchers concluded that the
vaccine, at low doses, appears safe and well tolerated, and that it
likely 'ameliorates the advanced autoimmune process underlying type 1
diabetes by stimulating TNF, which selectively kills only
disease-causing cells.'" Reuters (8/9, Begley) also covers the story.
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