MedPage Today (12/7, Kaiser) reports, "Some hypertension medications appear to be sensitive to a person's weight, a subanalysis of the ACCOMPLISH trial found." Investigators found that "the single-pill combination of benazepril (ACE inhibitor) plus the diuretic hydrochlorothiazide was associated with increasingly fewer cardiovascular events as patients' body mass index (BMI) rose." But, "BMI did not influence efficacy in patients taking benazepril plus amlodipine (calcium channel blocker)." The findings were published online in The Lancet.
HealthDay (12/7, Reinberg) reports that, according to lead researcher Dr. Michael Weber, a professor of medicine at Downstate Medical Center of the State University of New York in New York City, "Unexpectedly, people who have high blood pressure and are fat actually have a better prognosis than people who have high blood pressure and are thin." Dr. Weber added, "You can now choose blood pressure medication as a means of compensating for this difference between obese and thin people, so that it's possible to treat everybody with a medicine that maximizes the outcome regardless of how much you weigh."