MedPage Today 
(1/10, Neale) reports, "Adding a nonsteroidal anti-inflammatory drug (NSAID) to an antihypertensive regimen that includes a diuretic and either an ACE inhibitor or an angiotensin receptor blocker may increase the risk of acute kidney injury [AKI]," according to a study published online in BMJ. Researchers found that, "compared with patients on the dual antihypertensive regimen alone, those who also were taking an NSAID had a 31% greater risk of acute kidney injury (rate ratio 1.31, 95% CI 1.12 to 1.53)." The investigators reported that "the risk was highest within the first 30 days of using the antihypertensive-NSAID combination (rate ratio 1.82, 95% CI 1.35 to 2.46)."
(1/10, Neale) reports, "Adding a nonsteroidal anti-inflammatory drug (NSAID) to an antihypertensive regimen that includes a diuretic and either an ACE inhibitor or an angiotensin receptor blocker may increase the risk of acute kidney injury [AKI]," according to a study published online in BMJ. Researchers found that, "compared with patients on the dual antihypertensive regimen alone, those who also were taking an NSAID had a 31% greater risk of acute kidney injury (rate ratio 1.31, 95% CI 1.12 to 1.53)." The investigators reported that "the risk was highest within the first 30 days of using the antihypertensive-NSAID combination (rate ratio 1.82, 95% CI 1.35 to 2.46)."
Heartwire (1/10, Nainggolan) reports, "In an editorial accompanying the paper, Drs Dorothea Nitsch and Laurie A Tomlinson (London School of Hygiene and Tropical Medicine, UK)" write, "Clinicians must advise patients who are prescribed diuretics, ACE inhibitors, or ARBs of the risks associated with NSAID use, and they must also be vigilant for signs of drug-associated acute kidney injury in all patients."
(1/10, Nainggolan) reports, "In an editorial accompanying the paper, Drs Dorothea Nitsch and Laurie A Tomlinson (London School of Hygiene and Tropical Medicine, UK)" write, "Clinicians must advise patients who are prescribed diuretics, ACE inhibitors, or ARBs of the risks associated with NSAID use, and they must also be vigilant for signs of drug-associated acute kidney injury in all patients."
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