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Wednesday, July 9, 2014

Proton Pump Inhibitors Emerging as Important Contributor to Acute Interstitial Nephritis

In a retrospective study of 133 patients with biopsy-proven acute interstitial nephritis, drugs were the cause in 70% of cases, autoimmune diseases caused 20%, and infections caused 4%. Results showed that 49% of the drug-related cases were due to antibiotics, 14% were due to proton pump inhibitors, and 11% were due to non-steroidal anti-inflammatory agents. The top 3 drug causes were omeprazole (12%), amoxicillin (8%), and ciprofloxacin (8%). The American Journal of Kidney Diseases findingssuggest that the cause of acute interstitial nephritis may be shifting, with proton pump inhibitors emerging as an important contributor to this disease.

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