Omega-3 Fatty Acids Provide Small Improvement in Kidney Function after Myocardial Infarction

Long-term supplementation with 400 mg/d eicosapentaenoic acid–docosahexaenoic acid (EA–DA) provided a small beneficial effect on kidney function in the Alpha Omega Trial of 2344 patients with a history of myocardial infarction. After 40 months, the decline in creatinine–cystatin C-based GFR was 2.1 less mL/min/1.73 m² in patients receiving EA–DA compared to the placebo. Patients receiving EA–DA had a 17% decreased risk of incident CKD, and a 15% decreased risk of rapid kidney function decline (≥3 mL/min per year) compared to patients receiving a placebo. The findings are published in CJASN.