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Saturday, November 22, 2014

Plasma Lithium Levels Above Advised Range Tied to Transient Kidney Function Reduction

Medwire News reported that according to a study published Nov. 7 in the BMJ Open, “plasma levels of lithium above the advised range are associated with a transient reduction in kidney function.” The study of 699 patients “found a dose-response effect, with plasma lithium levels of 1.01–1.20mmol/L associated with a 3.88 percentage point reduction in estimated glomerular filtration rate (eGFR) measured within three months of the lithium value, while levels of 1.21–2.00 mmol/L were associated with a 5.40 percentage point reduction.” Such reductions remained “significant after accounting for age and gender.”

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