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Friday, November 29, 2013

Blacks Have Lower Levels of Total 25-Hydroxyvitamin D and Vitamin D–Binding Protein than Whites

In the 2085-participant Healthy Aging in Neighborhoods of Diversity across the Life Span cohort, average levels of both total 25-hydroxyvitamin D and vitamin D–binding protein (which keeps vitamin D from being used right away) were lower in blacks than in whites, leading to similar concentrations of bioavailable vitamin D overall. The NEJMfindings suggest that a low level of total 25-hydroxyvitamin D does not necessarily indicate a need to replace vitamin D. Racial differences in common genetic polymorphisms explained 79.4% and 9.9% of the variation in vitamin D–binding protein and total 25-hydroxyvitamin D levels, respectively.

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