Acute Respiratory Distress Syndrome Linked with Increased AKI Risk among Critically Ill Patients

Among 8029 patients with ICU stays >24 hours, AKI occurred in 44.3% of patients with acute respiratory distress syndrome (ARDS) compared to 27.4% of patients without ARDS. After adjusting for confounders, mechanical ventilation without ARDS was linked with fourfold increased odds of AKI, while ARDS was linked with 11-fold increased odds of AKI. Hospital mortality was higher in patients with ARDS (27.9% vs. 10.0% in patients without ARDS) and patients with AKI (27.6% vs. 8.1% in those without AKI). AKI was associated with higher mortality in patients with ARDS (42.3% vs. 20.2%) in the CJASN study.