Saturday, July 27, 2013
Fluoroquinolone Antibiotic Use Linked with Increased Risk of AKI.
Current use of fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin), which are common broad-spectrum antibiotics most often used to treat respiratory and urogenital infections, were linked to a 2.18-fold increased risk of acute kidney injury (AKI) in nearly 14,000 men aged 40 to 85 years who were enrolled in the US LifeLink Health Plan Claims Database between 2001 and 2011. There was no association between AKI and recent or past use. Concurrent use of an oral fluoroquinolone and a renin-angiotensin-system blocker was associated with a 4.46-fold increased risk of AKI. The findings were published in CMAJ.