Intermittent Renal Replacement Therapy Linked with Dialysis Dependence in AKI Patients.

In a systematic review and meta-analysis of 23 studies of dialysis dependence among survivors of severe acute kidney injury treated with either intermittent renal replacement therapy (IRRT) or continuous RRT (CRRT), pooled analyses of randomized clinical trials showed no difference in the rate of dialysis dependence among survivors. However, pooled analyses of observational studies found that patients receiving IRRT having a twofold increased risk of dialysis dependence. The analysis examined 23 studies that included seven randomized controlled trials with 472 patients and 16 observational studies with 3499 patients. The findings (7/26) are published in Intensive Care Medicine.