Kidney Donors Show Some Signs of Mild CKD 6 Months After Donation

In a prospective study comparing 203 kidney donors with 201 controls, donors had 28% lower GFR at 6 months (67.6 vs. 94.6 mL/min/1.73 m²), 23% higher parathyroid hormone (52.7 vs. 42.8 pg/mL), and 5.4% lower serum phosphate (3.3 vs. 3.5. mg/dL). They also had 3.7% lower hemoglobin (13.1 vs. 13.6 g/dL), 8.2% higher uric acid (5.3 vs. 4.9 mg/dL), 24% higher homocysteine (1.5 vs. 1.2 mg/L), and 1.5% lower HDL cholesterol (54.1 vs. 54.9 mg/dL) levels. The American Journal of Kidney Diseases study found no significant difference between donors and controls in albumin-creatinine ratios, office blood pressure levels, or glucose homeostasisin.