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Friday, May 25, 2012

Serum AIF-1 May Be Marker For Diabetic Nephropathy.

MedWire Share to FacebookShare to Twitter (5/10, Robertson) reports, "Serum allograft inflammatory factor-1 (AIF-1) could be a marker for diabetic nephropathy," according to a study Share to FacebookShare to Twitter published online May 4in the journal Diabetes Research and Clinical Practice. In 284 patients with type 2 diabetes, researchers found that "the mean AIF-1 concentration was significantly higher in patients with macroalbuminuria (>300 mg/g creatinine) than in those with microalbuminuria (30-300 mg/g creatinine) or normoalbuminuria (<30 mg/g creatinine), at 110.2 pg/mL versus 84.5 pg/mL and 75.6 pg/mL, respectively." What's more, "mean AIF-1 was significantly higher in patients who had an eGFR of less than 60 mL/min per 1.73 m2, compared with those who had an eGFR of 60-90 mL/min per 1.73 m2 or more than 90 mL/min per 1.73 m2, at respective concentrations of 99.3 pg/mL versus 40.4 pg/mL and 28.7 pg/mL, respectively."

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