Saturday, December 14, 2013
Cancer Drug Linked with Decreased Kidney Function
Patients taking crizotinib for the treatment of non-small cell lung cancer experienced an average 23.9% decrease in eGFR during the first 12 weeks of therapy in a recent Cancer study. The study included 38 patients on crizotinib therapy, and their reduced kidney function was most evident in the first 2 weeks of treatment. When crizotinib therapy was stopped, 56% of patients had complete recovery in their eGFR. The renal effects of crizotinib, which blocks a protein made by the mutated anaplastic lymphoma kinase gene, may need to be considered when determining the appropriate duration of crizotinib therapy.
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