A study of 1721 Japanese cancer patients treated with cisplatin as a first-line chemotherapy between 2006 and 2012 found that cisplatin dosages/m² or diagnosis of stage 4 cancer were risk factors of moderate cisplatin-induced acute kidney injury (AKI). Patients with a history of diabetes, a history of cardiovascular disease, or a diagnosis of stage 4 cancer were risk factors for severe cisplatin-induced AKI. The Oncology study investigators note that because severe cisplatin-induced AKI can shorten survival, physicians should carefully consider whether the use of cisplatin will benefit patients with these risk factors.
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