Saturday, December 14, 2013
Sodium Restriction May Increase Efficacy of RAAS Blockade
In patients with nondiabetic CKD, sodium restriction on top of single and dual renin-angiotensin-aldosterone system (RAAS) blockade increases circulating levels of the anti-inflammatory and antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), according to a secondary analysis of a 46-patient randomized clinical trial. Patients with overt proteinuria and mild-to-moderate renal insufficiency were subjected to four double-blind 6-week study periods with either a regular-sodium or low-sodium diet in addition to either lisinopril or lisinopril plus valsartan. The Journal of Hypertension analysis concludes the rise in AcSDKP may contribute to the enhanced cardiorenal protection of RAAS-blockade during sodium restriction.
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