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Saturday, December 14, 2013

Diabetes Drugs Affect Men’s and Women’s Hearts Differently

Metformin had a favorable effect on cardiac metabolism in women but an unfavorable one in men, according to a study of 78 patients with type 2 diabetes. Adding rosiglitazone mitigated some of the negative effects of metformin in men, and improved heart metabolism further in women. Adding Lovaza (an omega-3 fish oil) improved diastolic function, particularly in men. The American Journal of Physiology – Heart and Circulatory Physiology studyused PET, echocardiography, and whole body tracer studies before and 3 months after randomization to metformin, metformin + rosiglitazone, or metformin + Lovaza.

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