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Wednesday, February 5, 2014

Antihypertensive’s Effects Not Reduced in Patients with Low Kidney Function

A new study reports that low kidney function does not reduce the short-term effects of the antihypertensive chlorthalidone. The Hypertension study compared the effects of 8-week treatment with 25 mg chlorthalidone in addition to ongoing treatment in 60 hypertensive control patient and 60 hypertensive patients with low kidney function. By week 8, blood pressure decreased in both groups without significant between-group differences. Incidence of adverse events was similar in the two groups. Baseline estimated GFR did not predict blood pressure changes and adverse events in either group.

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