Increased Intensity of Renal Replacement Therapy Does Not Reduce Premature Mortality in Patients with AKI

Among 1464 patients with AKI in an intensive care unit who required renal replacement therapy (RRT), mortality rates and quality of life among those who survived were essentially the same in patients receiving low intensity RRT or high intensity RRT (63% vs. 62%). Albuminuria was common among survivors, with similar rates in both groups (40% in the low intensity group and 44% in the high intensity group). Patients in the Randomized Evaluation of Normal vs. Augmented Levels of RRT (RENAL) study were followed for a median of 43.9 months. The findings are published in PLOS ONE.