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Saturday, May 10, 2014

Autosomal Dominant Polycystic Kidney Disease Diminishes Exercise Capacity

Researchers found lower aerobic capacity in young normotensive ADPKD patients with preserved kidney function and inadequate responses of nitric oxide and asymmetric dimethylarginine (ADMA) levels to acute exercise, suggesting early endothelial dysfunction. Among 26 ADPKD patients and 30 controls, peak oxygen uptake and anaerobic threshold were lower in ADPKD patients. Postexercise serum and urinary nitric oxide levels in patients were not significantly different from baseline, while they increased in controls. Postexercise ADMA level was unchanged in patients, while it decreased in controls. A negative correlation between postexercise nitric oxide and ADMA levels occurred in only controls in the AJKD study.

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