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Sunday, May 25, 2014

Combined Effects of Genetic and Lifestyle Factors on Type 2 Diabetes Risk Quantified

The contribution of genetics to the risk of developing type 2 diabetes is greatest in younger and leaner individuals; however, this group is at low absolute risk, according to a study of >28,000 middle-aged individuals. The 10-year cumulative incidence of type 2 diabetes rose from 0.25% to 0.89% across extreme quartiles of the genetic score in normal weight individuals, compared with 4.22% to 7.99% in obese individuals. The high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than targeted lifestyle interventions. The findings are published in PLOS Medicine.

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