Critical Illness Linked with Significant and Sustained Decreases in Serum Creatinin

Critical illness was associated with significant decreases in serum creatinine from admission to discharge among 700 ICU patients (66% with AKI). In patients with known baseline creatinine, discharge creatinine was lower in all patients except those with severe AKI, who had no significant difference. Median hospital duration was associated with a 30% decrease in creatinine from baseline in the absence of AKI. After allowing for this effect, AKI was associated with a 29% increase in predicted hospital discharge creatinine. These effects can offset, potentially masking significant kidney dysfunction in survivors of critical illness complicated by AKI, according to theCJASN study.