Does Increased Water Intake Affect ADPKD Progression?

Among 34 autosomal dominant polycystic kidney disease (ADPKD) patients divided into high- and free-water–intake groups, urine volume increased in the high intake group but not in the free intake group over the course of the 1-year study. Total kidney volume and kidney function slopes were not significantly different between the groups, although they became worse in the high intake group but not in the free intake group when compared with a prestudy period. The Nephrology Dialysis Transplantation study concluded a long-term randomized study is necessary before conclusions may be drawn about the clinical effects of increased water intake on ADPKD progression.