(10/19, Phend) reports, "For critically ill patients, fluid resuscitation with hydroxyethyl starch is harder on the kidneys than standard saline without clinical benefits to compensate," according to a study published online in the New England Journal of Medicine. Investigators found that "patients on lower-molecular-weight hetastarch were 21% more likely to require dialysis." Meanwhile, "overall adverse event rates were higher with than with standard saline (5% versus 3%, P<0.001), although pruritus accounted for the largest proportion of these and serious events and mortality risk didn't differ between the two volume expansion treatments."
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