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(11/7, Susman) reports on a study presented at the American Heart Association meeting and published in the New England Journal of Medicine finding that ultrafiltration "was no better than aggressive diuretic therapy, and the device worsened kidney function." Also, the "treatment reduced weight by about 12 pounds without changing creatinine levels compared with a loss of about 12.5 pounds, but with a 0.2 mg/dL increase in creatinine." And "the difference achieved statistical significance showing that the pharmaceutical approach was superior to the device (P=0.003)." The study covered "94 patients to be treated with intravenous ultrafiltration, which is a mechanical device to draw water from the patient. A second group of patients were assigned to stepped pharmacological care in which diuretics were adjusted to remove 3 to 5 liters of urine a day." The study, called CARESS-HF, was funded by the National Heart, Lung, and Blood Institute.
(11/7, Susman) reports on a study presented at the American Heart Association meeting and published in the New England Journal of Medicine finding that ultrafiltration "was no better than aggressive diuretic therapy, and the device worsened kidney function." Also, the "treatment reduced weight by about 12 pounds without changing creatinine levels compared with a loss of about 12.5 pounds, but with a 0.2 mg/dL increase in creatinine." And "the difference achieved statistical significance showing that the pharmaceutical approach was superior to the device (P=0.003)." The study covered "94 patients to be treated with intravenous ultrafiltration, which is a mechanical device to draw water from the patient. A second group of patients were assigned to stepped pharmacological care in which diuretics were adjusted to remove 3 to 5 liters of urine a day." The study, called CARESS-HF, was funded by the National Heart, Lung, and Blood Institute.
Heartwire (11/7, Hughes) reports, "Ultrafiltration was associated with worsening renal function and more severe adverse events compared with optimum drug therapy in patients with acute decompensated heart failure." Lead author Bradley Bart, MD (Hennepin County Medical Center, Minneapolis, MN) concluded: "Ultrafiltration offers no advantage to stepped pharmacologic care in patients with acute decompensated heart failure, worsened renal function, and persistent congestion."
(11/7, Hughes) reports, "Ultrafiltration was associated with worsening renal function and more severe adverse events compared with optimum drug therapy in patients with acute decompensated heart failure." Lead author Bradley Bart, MD (Hennepin County Medical Center, Minneapolis, MN) concluded: "Ultrafiltration offers no advantage to stepped pharmacologic care in patients with acute decompensated heart failure, worsened renal function, and persistent congestion."
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