Drug Combination Protects Kidneys.

The combination of an angiotensin-converting enzyme inhibitor and a histone deacetylase inhibitor could maximally reverse the disease-associated expression of genes in the kidneys of a mouse model of HIV-associated nephropathy. The combination of these two inhibitors had an additive renoprotective effect by reducing proteinuria, improving kidney function, and attenuating kidney injury. The treatment also led to expected changes in the expression of certain disease-associated genes. The findings, published in the Journal of the American Society of Nephrology, suggest that this combination could have therapeutic potential for various kidney diseases.