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Thursday, March 22, 2012

Antiplatelet Treatment May Not Improve Outcomes For Patients With Chronic Kidney Disease.

MedPage Today Share to FacebookShare to Twitter (3/21 Walsh) reports that "the use of antiplatelet therapy among patients with chronic kidney disease (CKD) does not appear to improve cardiovascular outcomes and may worsen the likelihood of bleeding," according to a systematic review published in the March 20 issue of Annals of Internal Medicine. Specifically, there was little risk reduction for myocardial infarction following antiplatelet therapy, but the risk of major bleeding events did increase. According to the researchers, the evidence was "low or very low quality" with "substantial methodological limitations."
        "We have shown, for the first time, that the potential benefits of antiplatelet drugs in people with renal disease may actually be outweighed by the harms, in particular bleeding," senior author Dr. Giovanni Strippoli told Heartwire Share to FacebookShare to Twitter (3/21, Nainggolan). "The trade-off between benefits and harms should always be carefully assessed before prescribing these [antiplatelet] drugs to people with CKD," he adds.

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