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Friday, March 9, 2012

Vitamin D May Not Improve Heart Health In People With CKD.

HealthDay Share to FacebookShare to Twitter (2/15, Preidt) reports, "Vitamin D therapy does not improve heart health in people with chronic kidney disease [CKD]," according to a study Share to FacebookShare to Twitter published in the Journal of the American Medical Association.
        MedPage Today Share to FacebookShare to Twitter (2/15, Walsh) reports, "After 48 weeks of treatment, the change in left ventricular mass was similar among patients receiving the active vitamin D compound paricalcitol (Zemplar) and patients receiving placebo (0.34 g/m2.7 compared with -0.07 g/m2.7, P=0.06)." Researchers also found that "there was no difference in peak early diastolic lateral mitral annular tissue velocity, which was −0.01 cm/second in the vitamin D group and −0.30 cm/second in the placebo group (P=0.93)."
        HeartWire Share to FacebookShare to Twitter (2/15, Wood) reports that "cardiac hospitalizations were slightly lower in the vitamin-D group as compared with the placebo group, while increases in plasma B-type natriuretic-peptide (BNP) were less marked in the paricalcitol group; paricalcitol also increased serum creatinine and decreased creatinine-based measures of estimated glomerular filtration rate (eGFR)." The investigators also found that "patients taking paricalcitol also had a slightly higher number of adverse events, mostly due to hypercalcemia."

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