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Thursday, March 8, 2012

Y Chromosome Variants May Play Role In Heart Disease.

The New York Times Share to FacebookShare to Twitter (2/9, A13, Kolata, Subscription Publication) reports that a study published in The Lancet suggests "the Y chromosome, the one chromosome unique to men," may play a role in heart disease.
        HealthDay Share to FacebookShare to Twitter (2/9, Preidt) reports that investigators "analyzed DNA from more than 3,000 biologically unrelated men in the United Kingdom and found that 90 percent had variants of Y chromosomes belonging to one of two major groups -- haplogroup I and haplogroup R1b1b2." Individuals "with a Y chromosome from haplogroup I have a 50 percent higher risk of coronary artery disease than other men, and that risk is independent of risk factors such as smoking, high blood pressure and high cholesterol, the researchers found."
        WebMD Share to FacebookShare to Twitter (2/9, Goodman) reports, "Haplogroup I was the third most powerful predictor that men would develop heart disease, behind their HDL...cholesterol levels, and whether or not they were taking cholesterol-lowering drugs. Experts estimate that about 20% of men in Europe and 10% of men in the US belong to haplogroup I."
        BBC News Share to FacebookShare to Twitter (2/9, Roberts) reports that lead researcher Dr. Maciej Tomaszewski "said, ultimately, the discovery could lead to new ways to treat and prevent heart disease in men, as well as a genetic test to spot those greatest risk."
        HeartWire Share to FacebookShare to Twitter (2/9, Nainggolan) reports, "In an accompanying comment, Dr. Virginia M Miller (Mayo Clinic Rochester, MN) says the new research 'provides insight into genetic variants and potential new approaches to the understanding of inheritable coronary artery disease in men.'"
        The UK's Telegraph Share to FacebookShare to Twitter (2/9, Smith) reports, "The study...was conducted by a team at University of Leicester and University of Ballarat in Australia and may also help explain why heart disease is more common in northern European countries compared with the south as the Y variation is more common there." The UK's Press Association Share to FacebookShare to Twitter (2/9) also covers the story.
        Large Ex-NFL Players May Face Higher Risk Of Dying From Heart Disease. Reuters Share to FacebookShare to Twitter (2/9, Norton) reports that, according to research published in the American Journal of Cardiology, the largest professional football players may face a higher risk of dying from heart disease. Investigators looked at data on about 3,400 former NFL players. Those who were the largest during their playing years faced an increased risk of death from stroke or heart disease. Specifically, defensive linemen faced a 42 percent higher risk of dying from heart disease compared with US males overall.

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